Pyoderma gangrenosum: challenges and solutions
نویسندگان
چکیده
منابع مشابه
Pyoderma gangrenosum: challenges and solutions
Pyoderma gangrenosum (PG) is a rare disease, but commonly related to important morbidity. PG was first assumed to be infectious, but is now considered an inflammatory neutrophilic disease, often associated with autoimmunity, and with chronic inflammatory and neoplastic diseases. Currently, many aspects of the underlying pathophysiology are not well understood, and etiology still remains unknown...
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Pyoderma gangrenosum (PG) is an idiopathic, ulcerative, noninfective chronic inflammatory skin disorder of unknown etiology. It is associated with systemic medical illness in 50% of cases like inflammatory bowel disease, systemic arthritis, haematological diseases and malignancies. Characteristic lesions begin as pustule or vesiculopustule and progresses to an ulcer or deep erosion with violace...
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710 started an oral ibrutinib therapy (3 × 140 mg/d), due to B-CLL. An ulcer biopsy revealed lymphocyte and neutrophil infiltration. No histopathologic signs of carcinoma or vasculitis were observed. After consultation with a hematologist, a tentative diagnosis of ibrutinib-induced pyoderma gangrenosum (PG) was established. In addition to ibrutinib discontinuation, daily prednisone dose was inc...
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Pyoderma gangrenosum (PG) is a rare noninfectious neutrophilic dermatosis. Clinically it starts with sterile pustules that rapidly progress and turn into painful ulcers of variable depth and size with undermined violaceous borders. The legs are most commonly affected but other parts of the skin and mucous membranes may also be involved. Course can be mild or malignant, chronic or relapsing with...
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ژورنال
عنوان ژورنال: OncoTargets and Therapy
سال: 2015
ISSN: 1178-6930
DOI: 10.2147/ott.s61202